PDF Ebook , by George M. Church
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, by George M. Church
PDF Ebook , by George M. Church
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Product details
File Size: 2291 KB
Print Length: 306 pages
Page Numbers Source ISBN: 0465075703
Publisher: Basic Books (April 8, 2014)
Publication Date: April 8, 2014
Language: English
ASIN: B06XBVB2GH
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I am glad I read this book while writing mine on “Steering Human Evolution.†We converge in using the term “regenesis†and in considering leaping human evolution-resetting powers, though we differ in background and focus: This book deals with the significance, promises and technologies of synthetic biology, while I as a contemplative policy-scientist deal with the fateful choices on developing and using such knowledge and the requirements of steering regenesis for the better.The text is enlightening and covers well its core subject, bur there are a number of small problems and a major one. The small ones are illustrated by taking the Flynn effect seriously (p. 88) though it is very doubtful and surely too narrow; and hubris statements such as humanity making an “effort to colonize the universe†(p. 252). Also, the statement that “we continue our crusade for increased diversity†(p, 71) raises serious issues. Too much diversity may well break human societies. And reintroduction of Neanderthals (p. 141) would raise hair-raising moral and legal problems and have unpredictably and not necessarily beneficial consequences. I like the iconoclastic idea of “very specialized and highly trained parenting—well beyond the current random assignment of child to parent (p. 224). But this leads to the critical issue ignored in the book, namely who shall decide on and enforce glonslly required safeguards and regulations?Thus, the statement than “the march toward transhumanism, is not knowable in advance, it is at least within human control. And that should be a comforting thought (p. 242) is daydreaming. To globally control such processes, including in rogue states, requires nothing less than a strict global regime, up to a Conscientious Global Leviathan. The book quotes, rightly so, the view of Kurzweil that future technological change will be so rapid and profound that it will constitute “a rupture in the fabric of human history†(p. 242). But it does not draw the compelling conclusion namely, as i put it in one of my books “it is absurd to believe that everything is going to change, but politics will and can remain the same.“ The statement “probably no eugenics (government control of genetic inheritance) but heavily laden with W-genics (you-eu-genics, individual control over their own body genetics) and euphenics (changing traits by changing environments, drugs, and devices) (p. 261) raises the right questions, but is not aware of its doubtful assumptions and raises harsh issues rather them coping with them. A book on regenesis technologies is not obliged to consider socio-political implications. But the authors do make comments on them. If so the fundamental question who shall make all the fateful choices should at least be raised. Not doing so is, in my view, a serious lacunae. But in no way does it diminish the excellence of the book as far as emerging gene engineering and related technologies are concerned.Professor Yehezkel Dror
I've met people who really like this book, and people who hate it. I am one of the people who really liked it.This is one of the most interesting science books I've ever read (with my major being molecular and cellular biology). He brought up so many revolutionary, interesting things you can do with synthetic biology, from resurrecting extinct animals like the Pyrenean Ibex, to using E. Coli to fight cancer. Oh and biobricks. Can't forget biobricks. Or mirror life.I will admit that it is very very long. Not in terms of pages, but in terms of the complexity of his ideas. Nothing in science is simple, and Church knows that. I actually appreciated this. A lot of science books out there dumb it down for the general population, but Church didn't (at least not to the same extent). We me being a researcher, it was really nice.
A bit of a dense book (which is why I gave it only 4 stars). But if you read it through, a world will open for you. The book is about synthetic genetics -- how the advances that are happening right now, but especially in the decades to come, will change the world and blow your mind. There is a lot in this book. But I would like to just talk about my favorite part -- the iGEM competition. iGEM is an international student competition for genetic engineering. As Church says [referring to the year 2005], "Undergrads were now doing things, largely in a spirit of fun, that professional molecular biologists would have been hard-pressed to achieve a mere ten years earlier." In the 2007 competition, the team from UC Berkeley engineered E. coli to produce a blood substitute that could be freeze-dried and stored, and then could be reconstituted and grown up in large volumes when needed. In 2008, the grand prize winner was a Slovenian team from the University of Ljubljana which created a synthetic vaccine for the bacteria that causes stomach ulcers. In 2006, the same Slovenian team had presented an idea for preventing infection of human cells by HIV. In 2010 the competition had grown from the original four teams (in 2005) to 130 teams from all over the world: Asia (38), Europe (38), the US (37), Canada (10), Latin America (4) and Africa (1). The ideas presented by these student teams were amazing, inspiring, brilliant. A team from the Swiss Federal Institute of Technology at Lausanne aimed to stop malaria propagation by acting on the vector, that is, the mosquito itself, by coaxing the bacterium that naturally lives in the mosquito's gut to express an immunotoxin that can prevent the malarial agent from infecting the mosquito, thereby eliminating transmission of the parasite to humans. A team from Polytechnic University of Valencia, Spain had a plan to change the climate of Mars (yes, the planet) by building an engineered yeast, resistant to temperature changes and able to produce a dark pigment which will be responsible for a global temperature increase.(They received a gold prize for their efforts). A team from the University of Washington in Seattle were attempting to synthesize antibiotics, starting with Anthrax for the competition. In my view, this is an idea of staggering proportions given the current crisis in antibiotic resistance. (This same same team went on to win the North American competition the following year for engineering E. coli to produce both diesel fuel and an enzyme to break down gluten in the digestive tract.) Also receiving a gold prize was a team from the Chinese University of Hong Kong for creating a living data storage system. Apparently, you no longer need to rely exclusively on micro-chips anymore to store an absurd amount of data in a small space. And the big winner was once again the team from Slovenia for coming up with an "assembly-line" molecule for DNA engineering. I don't pretend to fully understand it, but Church likens it to the moment in the industrial revolution when standardized nuts and bolts, machine-tools and assembly-line production systems were introduced. There was a time when to build a machine you had to build everything basically from scratch, custom made and hand-tooled. But around the turn of the 18th century a wave of standardized machinery became the norm, accelerating the process of invention and industrialization exponentially. Apparently, the judges thought the "assembly-line" molecule was potentially at that level of importance. Church's larger point here is that we are on the cusp of assembly-line genetic engineering. Expect an explosion in innovation.
I wish I were young again. I would have loved to have studied this stuff and then done something with it. This book is the first thing in a very long while that gives me hope and enthusiasm for the future. Come on kids, including my bright nephew who is getting a copy of this, get going on this stuff so we can all live past a hundred! Before it's too late!!Although I took and enjoyed high school chemistry, I am not in science or technology at all, but I loved reading this book. The subject is fascinating but the authors write wonderfully and with humor, which has been most appreciated. -JEH
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